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Functional brain imaging shows many specializations in the human brain. At the same time, it reveals something unexpected – a specific set of regions in the frontal and parietal cortex, active for many different kinds of cognitive demand. We call this '''multiple-demand or MD cortex'''. The network was originally defined using predominantly PET data: A number of regions in the frontal and parietal cortex show extreme domain generality, with a similar pattern of activity for many different kinds of cognitive demand. We call this '''multiple-demand or MD cortex'''.
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[http://www.mrc-cbu.cam.ac.uk/bibliography/articles/4062/ [Duncan and Owen, 2000]] [[http://www.mrc-cbu.cam.ac.uk/bibliography/articles/6132/ Duncan, 2006]] To define MD regions, activity can be averaged from a diverse set of tasks. Seven tasks were used in:
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The definition of the MD system has been further refined using fMRI data from seven different tasks of varying demand, described in the publication:

'''Fedorenko, E., Duncan, J., & Kanwisher, N. (in press). Language-selective and Domain-general Regions Lie Side by Side within Broca's Area. ''Current Biology''. '''
'''Fedorenko, E., Duncan, J., & Kanwisher, N. (submitted). Extreme domain-generality in specific regions of frontal and parietal cortex.'''
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The units are t-statistics from contrasts that isolate cogntive demand, averaged across the seven tasks. The figure below shows the main foci of the multiple demand system when this volume is thresholded at a value of t>1.5. The units are t-statistics from contrasts that isolate cognitive demand, averaged across the seven tasks. To create a symmetrical volume, data from left and right hemispheres were averaged, then projected back to both hemispheres. The figure below shows the main foci of the multiple demand system when this volume is thresholded at a value of t>1.5..

A number of regions in the frontal and parietal cortex show extreme domain generality, with a similar pattern of activity for many different kinds of cognitive demand. We call this multiple-demand or MD cortex.

To define MD regions, activity can be averaged from a diverse set of tasks. Seven tasks were used in:

Fedorenko, E., Duncan, J., & Kanwisher, N. (submitted). Extreme domain-generality in specific regions of frontal and parietal cortex.

[attachment:NiftiVolume.nii.gz The full unthresholded volume can be downloaded in Nifti format from this link].

The units are t-statistics from contrasts that isolate cognitive demand, averaged across the seven tasks. To create a symmetrical volume, data from left and right hemispheres were averaged, then projected back to both hemispheres. The figure below shows the main foci of the multiple demand system when this volume is thresholded at a value of t>1.5..

attachment:MDmedial.png attachment:MDlateral.png

CbuImaging: MDsystem (last edited 2016-10-26 14:07:43 by DannyMitchell2)